Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease
نویسندگان
چکیده
منابع مشابه
Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease
Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuri...
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The hypothesis that oxidized LDL (ox-LDL) is necessary, if not obligatory, in the development of atherosclerotic lesions was formulated .20 years ago with the seminal observation that uptake of native LDL by macrophages did not result in foam cell formation. In contrast, uptake of ox-LDL via scavenger receptors resulted in the unregulated accumulation of lipid.1 Since then, multiple studies in ...
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ژورنال
عنوان ژورنال: Chronic Diseases and Translational Medicine
سال: 2017
ISSN: 2095-882X
DOI: 10.1016/j.cdtm.2017.02.008